Hexahydrocannabihexol , known by the abbreviation HHCH, is a semi-synthetic cannabinoid that is not found naturally in cannabis, even in trace amounts. This distinctive element differentiates it from other minor cannabinoids often also produced (semi-)synthetically such as HHC, THCB , THCP , THCH or THCJD .
Formation and chemical composition of HHCH
HHCH takes the form of a thick, high viscosity oil. It is produced by hydrogenation of tetrahydrocannabihexol (THCH) distillate, this process transforming it into HHCH. When slightly heated, it becomes more malleable and can undergo color changes during oxidation, without losing potency or undergoing chemical transformation.
Its molecular formula is C22H34O2 and, since this substance is formed by hydrogenation, it consists of two different stereoisomers, the molecules 9(R)-HHCH and 9(S)-HHCH, similar to HHC and H4CBD. The 9(R) stereoisomer binds very effectively to CB1 receptors of the endocannabinoid system (ECS), causing a psychoactive effect, while 9(S) is considered the inactive component.
These compounds were first synthesized in 1942 by American chemist Roger Adams, who noted in his study that HHCH was more potent than its pentyl and heptyl counterparts or the unsaturated analogue tetrahydrocannabinol (THC).
Effects of HHCH
Roger Adams has reported that HHCH is a potent substance, suggesting that it may be 10 to 15 times stronger than THC and slightly superior in effectiveness. Although research to confirm this information is still limited, HHCH is generally reported to have psychoactive effects comparable to THC. Compared to HHCP, it shows slightly weaker effects and a longer duration of action compared to HHC, with effects lasting between 2 and 8 hours.
Most of the effects of cannabinoids depend on their interaction with the ECS in the body. HHCH, like other cannabinoids, interacts with this system, and early information suggests that it binds most effectively to CB1 receptors, found in the central nervous system and the brain, and also interacts with CB2 receptors, which found in the immune system, digestive tract and other organs.
Side effects of HHCH and other pitfalls
(Semi-)synthetic compounds can be much more potent than natural cannabinoids, increasing the potential risk of intoxication and overdose, which can lead to a bad trip. Negative psychological effects include paranoia, anxiety, panic and hallucinations.
Possible side effects include:
- Increased heart rate
- Fatigue and drowsiness
- Dry mouth
- Eye redness
- Headache
- Nausea and vomiting
Legality and HHCH products available
Hexahydrocannabihexol is currently defined as legal under the US Farm Bill, an agricultural law that excludes cannabis containing up to 0.3% THC from the list of controlled substances, thereby legalizing all cannabis derivatives. However, due to its psychoactive properties, it often falls into a legal gray area in some countries and may also face restrictions or bans. Currently in France, it is neither legal nor illegal, which makes it de facto legal at present.
HHCH products consist of two stereoisomers, 9(R)-HHCH and 9(S)-HHCH, and the ratio of these molecules affects the potency and strength of the product. HHCH vape pens, replaceable cartridges, and liquids are available in the cannabis market designed for vaping, as well as flower, hash, oils, and spirits.
It is recommended to always request laboratory analysis, focus on the composition of the product to ensure that it does not contain inappropriate ingredients, choose reliable and proven companies that test their products in an independent laboratory, and 'approach use responsibly and moderately.
Advice for consumers and the choice of HHCH products
Before purchasing and using products containing HHCH, it is crucial to fully understand their composition and potential. As previously mentioned, this cannabinoid is considerably more intense than natural cannabinoids, increasing the potential risk of overdose and intoxication. Here are some recommendations for safely navigating the world of HHCH products:
- Always Request Laboratory Analysis: Before purchasing HHCH products, demand to see third-party laboratory reports that verify the product's purity and regulatory compliance, including THC limits. These reports provide objective data on product purity, regulatory compliance, safety and more.
- Read the ingredients carefully: Inspect the ingredient list to ensure the product does not contain inappropriate additives, fillers or toxins. Premium products must be free of residual solvents, unnatural isomers and other unrecognized compounds.
- Choose reputable companies: Go for companies that have an established presence in the cannabis market and are transparent about their manufacturing processes and testing results. Companies that provide complete and detailed information about their products are generally more reliable.
- Responsible Use: Due to its potency, HHCH is only recommended for experienced cannabis users. Novices should avoid such powerful cannabinoids. Additionally, it is strongly advised not to drive or operate heavy machinery after consuming HHCH due to its marked psychoactive effects.
- Moderation in consumption: As with any psychoactive product, moderation is key. Start with small doses, especially if you're not used to the effects of powerful cannabinoids like HHCH, and adjust based on your reaction.
Legal perspectives and availability
Despite the legalization of cannabis for medical and recreational purposes in many countries, semi-synthetic cannabinoids like HHCH can still navigate a legal gray area. In Europe, for example, laws vary greatly between countries, and it is essential to inquire about local regulations before acquiring or consuming HHCH products. Compliance with local legislation not only protects the consumer but also ensures the long-term viability of businesses operating in this sector.
HHCH products, although available in various forms such as vape pens, cartridges, vape liquids, as well as flower and enriched oils, should be chosen with caution. The quality of the source and clarity of the information provided play a crucial role in determining its safety and effectiveness.
In conclusion, as the cannabinoid field continues to expand with innovative compounds like HHCH, consumers should remain informed and cautious. Education about the characteristics, effects, potential dangers, and relevant legislation is essential for anyone wishing to explore this modern frontier of therapeutic and recreational cannabis.